eViralHepatitis Review
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  VOLUME 2 – ISSUE 10
HBV Reactivation
Our guest author is David Wong, MD, Assistant Professor of Medicine at University of Toronto's Health Network and Clinical Director of the Francis Family Liver Clinic at Toronto Western Hospital in Toronto, Ontario, Canada.

After participating in this activity, the participant will demonstrate the ability to:

Explore the various presentations of HBV reactivation
Distinguish between effective and ineffective HBV antiviral therapy
Develop an approach to diagnosing acute hepatitis B

This discussion, offered as a downloadable audio file and companion transcript, covers the important issues related to Human Immunodeficiency Virus and hepatitis C virus coinfection in the format of case-study scenarios for the clinical practice. This program is a follow up to the Volume 2, Issue 9 eViralHepatitis Review newsletter —HBV Reactivation.


Unlabeled/Unapproved Uses
Dr. Wong's presentation today will include discussion of the off-label or unapproved uses of lamivudine, entecavir, and tenofovir. These agents are approved only for treatment of chronic HBV infection, not HBV reactivation.

David Wong, MD

David Wong, MD
Assistant Professor of Medicine
University Health Network
University of Toronto
Toronto, Ontario, Canada


Faculty Disclosure
Dr. Wong has indicated that he has no financial interests or relationships with a commercial entity whose products or services are relevant to the content of his presentations.

Release Date
October 4, 2012
Expiration Date
October 3, 2014
 
Mark S. Sulkowski, MD
Professor of Medicine
Medical Director, Viral Hepatitis Center
Divisions of Infectious Disease and Gastroenterology/Hepatology
The Johns Hopkins University School
of Medicine
Baltimore, Maryland
Raymond T. Chung, MD
Associate Professor of Medicine
Director of Hepatology, Medicine Services
Harvard Medical School
Vice Chief of Gastroenterology
Massachusetts General Hospital
Boston, Massachusetts
Julie McArthur, MS, CRNP
Adult Nurse Practitioner
Division of Infectious Disease
The Johns Hopkins University School
of Medicine
Baltimore, Maryland
 Accreditation Statements
Physicians
This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of The Johns Hopkins University School of Medicine and The Institute for Johns Hopkins Nursing. The Johns Hopkins University School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Nurses
The Institute for Johns Hopkins Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation.

The Institute for Johns Hopkins Nursing and the American Nurses Credentialing Center do not endorse the use of any commercial products discussed or displayed in conjunction with this educational activity.


credit designations
Physicians
eNewsletter: The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category1 Credit(s)�. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Podcast:
The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit(s)�. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses
Newsletter: This 1 contact hour Educational Activity is provided by The Institute for Johns Hopkins Nursing. Each newsletter carries a maximum of 1 contact hour or a total of 7 contact hours for the 7 newsletters in this program.

Podcast: This 0.5 contact hour Educational Activity is provided by the Institute for Johns Hopkins Nursing. Each podcast carries a maximum of 0.5 contact hour or a total of 2.5 contact hours for the 5 podcasts in this program.


Successful Completion
To successfully complete this activity, participants must read the content, and then link to the Johns Hopkins University School of Medicine's website or the Institute for Johns Hopkins Nursing’s website to complete the post-test and evaluation. Once you receive a passing grade, you can access and print your certificate of credit.

NOTE: If you have already registered for other Hopkins CME programs on their prospective websites simply enter the requested information when prompted.

There are no fees or prerequisites for this activity.

This activity is supported by an educational grant from Gilead Sciences, Inc. and Vertex Pharmaceuticals.


Launch Date
December 15, 2011; activities expire 2 years from the date of publication.

Length of Activity: 30 minutes


Internet CME Policy
The Office of Continuing Medical Education (CME) at the Johns Hopkins University School of Medicine is committed to protecting the privacy of its members and customers. The Johns Hopkins University SOM maintains its Internet site as an information resource and service for physicians, other health professionals, and the public.

Continuing Medical Education at the Johns Hopkins University School of Medicine will keep your personal and credit information confidential when you participate in an Internet-based CME program. Your information will never be given to anyone outside of the Johns Hopkins University School of Medicine program. CME collects only the information necessary to provide you with the services that you request.


Disclaimer Statement
The opinions and recommendations expressed by faculty and other experts whose input is included in this program are their own. This enduring material is produced for educational purposes only. Use of the Johns Hopkins University School of Medicine name implies review of educational format design and approach. Please review the complete prescribing information for specific drugs or combinations of drugs, including indications, contraindications, warnings, and adverse effects, before administering pharmacologic therapy to patients.


Statement of Responsibility
The Johns Hopkins University School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.

Statement of Need
Through discussions with experts in the specialty of HBV, a survey of participants from previous Johns Hopkins CME activities, and a review of current literature, the following core learning gaps have been identified:
Clinicians do not effectively identify their patients at risk for, or infected with, HBV
Clinicians lack the ability to interpret positive HBV screening
Clinicians do not adequately counsel their patients regarding their HBV status (for treatment or vaccination)
Clinicians do not properly treat, monitor, or refer their HBV patients, and moreover, they lack awareness of current treatments and emerging research

Intended Audience
This activity has been developed for hepatologists, primary care physicians, infectious disease specialists, nurses, nurse practitioners, and others involved in the care of patients with viral hepatitis.

Planner disclosures
As a provider accredited by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of the Johns Hopkins University School of Medicine Office of Continuing Medical (OCME) to require signed disclosure of the existence of financial relationships with industry from any individual in a position to control content of a CME activity sponsored by OCME. Members of the Planning Committee are required to disclose all relationships, regardless of their relevance to the activity content. Faculty are required to disclose only those relationships that are relevant to their specific presentations. The following relationships have been reported for this activity:
Mark S. Sulkowski, MD, has disclosed that he has served as a consultant for Abbott, Boehringer Ingelheim Pharmaceuticals, Inc., Bristol Myers-Squibb, Janssen, Merck, Novartis, Pfizer, Roche, and Vertex Pharmaceuticals. He has also received grants and research support from Abbott, Boehringer Ingelheim Pharmaceuticals, Inc., Bristol Myers-Squibb, Gilead, Janssen, Merck, Roche, and Vertex Pharmaceuticals.
Raymond T. Chung, MD, has disclosed that he has received grants/research support from Gilead, Pfizer, Roche/Genentech, Merck, and Romark.
No other planners have indicated that they have any financial interests or relationships with a commercial entity.
Guest Author Disclosures

Confidentiality Disclaimer for CME Conference Attendees
I certify that I am attending a Johns Hopkins University School of Medicine CME activity for accredited training and/or educational purposes.

I understand that while I am attending in this capacity, I may be exposed to “protected health information,” as that term is defined and used in Hopkins policies and in the federal HIPAA privacy regulations (the “Privacy Regulations”). Protected health information is information about a person�s health or treatment that identifies the person.

I pledge and agree to use and disclose any of this protected health information only for the training and/or educational purposes of my visit and to keep the information confidential.

I understand that I may direct to the Johns Hopkins Privacy Officer any questions I have about my obligations under this Confidentiality Pledge or under any of the Hopkins policies and procedures and applicable laws and regulations related to confidentiality. The contact information is: Johns Hopkins Privacy Officer, telephone: 410-735-6509, e-mail: HIPAA@jhmi.edu.

“The Office of Continuing Medical Education at the Johns Hopkins University School of Medicine, as provider of this activity, has relayed information with the CME attendees/participants and certifies that the visitor is attending for training, education and/or observation purposes only.”

For CME Questions, please contact the CME Office at (410) 955-2959 or e-mail cmenet@jhmi.edu.

Johns Hopkins University School of Medicine
Office of Continuing Medical Education
Turner 20/720 Rutland Avenue
Baltimore, Maryland 21205-2195

Reviewed & Approved by:
General Counsel, Johns Hopkins Medicine (4/1/03)

Updated 4/09


hardware & software requirements
Pentium 800 processor or greater, Windows 98/NT/2000/XP/7 or Mac OS 9/X, Microsoft Internet Explorer 5.5 or later, 56K or better modem, Windows Media Player 9.0 or later, 128 MB of RAM, sound card and speakers, Adobe Acrobat Reader, storage, Internet connectivity, and minimum connection speed. Monitor settings: High color at 800 x 600 pixels.
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Presented by JHUSOM and IJHN in collaboration with DKBmed.