Our guest authors are Paul Martin, MD, FRCP, FRCPI, Professor of Medicine and Kalyan Ram Bhamidimarri, MD, MPH, Assistant Professor of Clinical Medicine at the University of Miami School of Medicine.

• Discuss how direct-acting antiviral agents target the HCV life cycle and how they differ from prior interferon-based regimens.
• Describe the current data on direct-acting antiviral combinations for the treatment of HCV in HIV-HCV coinfected patients.
• Summarize the current evidence providing guidance on HCV treatment options in patients with end-stage renal disease who need urgent treatment.

This discussion, offered as a downloadable audio file and companion transcript, covers the important topic of HCV treatment in the clinic in the format of case-study scenarios for the clinical practice. This program is a follow up to the Volume 4, Issue 6 eViralHepatitis Review newsletter—The HCV Viral Life Cycle and Treatment in HIV Coinfection and Dialysis Populations.

Unlabeled/Unapproved Uses
Dr. Paul Martin and Dr. Kalyan Ram Bhamidimarri have indicated that there will be reference to the use of direct-acting antiviral agents in patients with severe renal impairment or end-stage renal disease who are on hemodialysis and need urgent hepatitis C treatment.

MEET THE AUTHORS
	Paul Martin, MD, FRCP, FRCPI Professor of Medicine, Chief Division of Hepatology University of Miami School of Medicine Miami, Florida Kalyan Ram Bhamidimarri, MD, MPH Assistant Professor of Clinical Medicine Medical Director for Small Bowel & Multi-Visceral Transplantation University of Miami School of Medicine Miami Transplant Institute

Guest Faculty Disclosure
Dr. Paul Martin has disclosed that he has received grant support from Gilead Sciences, Inc. and Merck & Co. Dr. Kaylan Ram Bhamidimarri has indicated that he has served as an advisor for and received research grant support from Bristol-Myers Squibb, Gilead Sciences, Inc., Janssen, and AbbVie. He has also received research grant funding from Biotest.

Mark S. Sulkowski, MD
Professor of Medicine
Medical Director, Viral Hepatitis Center
Divisions of Infectious Diseases and Gastroenterology
Johns Hopkins University School of Medicine
Baltimore, Maryland

Raymond T. Chung, MD
Director of Hepatology and Liver Center
Vice Chief, Gastroenterology
Kevin and Polly Maroni Research Scholar
Massachusetts General Hospital
Johns Hopkins University School of Medicine
Harvard Medical School
Boston, Massachusetts

Julie McArthur, MS, CRNP
Adult Nurse Practitioner
Division of Infectious Disease
Johns Hopkins University School of Medicine
Baltimore, Maryland

ACCREDITATION STATEMENT

Physicians
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Johns Hopkins University School of Medicine and The Institute for Johns Hopkins Nursing. The Johns Hopkins University School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Nurses
The Institute for Johns Hopkins Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation.

CREDIT DESIGNATION STATEMENT

Physicians
Podcast: The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses
Podcast: This 0.5 contact hour Educational Activity is provided by the Institute for Johns Hopkins Nursing. Each Podcast carries a maximum of 0.5 contact hour, or a total of 3 contact hours for the 6 podcasts in this program.

All rights reserved - The Johns Hopkins University School of Medicine.

This activity was developed in collaboration with DKBmed.