• Describe the key clinical considerations when selecting a retreatment regimen for patients who have failed previous therapy with DAA agents.
• Describe the key clinical considerations when selecting a retreatment regimen for patients who have failed previous therapy with peginterferon and ribavirin.
• Describe the key clinical considerations when selecting a treatment regimen for patients with renal impairment.

Guest Faculty Disclosure
Dr. Jacobson has disclosed that he has served as a consultant and/or advisor to AbbVie, Inc., Bristol-Myers Squibb, Gilead Sciences, Inc., Janssen, Merck & Co., Inc., and Trek. 

Unlabeled/Unapproved Uses
Dr. Jacobsonson has indicated that he will make reference to the unlabeled or unapproved uses of DAA combinations no longer in general use, experimental DAA combinations presented at recent society meetings, specific discrepancies between package inserts and the AASLD published guidelines, and the potential use of sofosbuvir outside of indication in patients with certain degrees of renal disease and uncompensated cirrhosis. 

ACCREDITATION STATEMENT
Physicians
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Johns Hopkins University School of Medicine and the Institute for Johns Hopkins Nursing. The Johns Hopkins University School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Nurses
The Institute for Johns Hopkins Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation.
 

CREDIT DESIGNATION STATEMENT
Physicians
Podcast: The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurses
Podcast: This 0.5 contact hour Educational Activity is provided by the Institute for Johns Hopkins Nursing. Each podcast carries a maximum of 0.5 contact hour, or a total of 3 contact hours for the 6 podcasts in this program.

POLICY ON SPEAKER AND PROVIDER DISCLOSURE
It is the policy of the Johns Hopkins University School of Medicine and the Institute for Johns Hopkins Nursing that the speaker and provider globally disclose conflicts of interest. The Johns Hopkins University School of Medicine OCME has established policies in place that will identify and resolve all conflicts of interest prior to this educational activity. Detailed disclosure will be made in the instructional materials.

All rights reserved - The Johns Hopkins University School of Medicine. Copyright 2018.

This activity was developed in collaboration with DKBmed.